abstract：:The present study is to measure the expression of programmed death (PD)-1 / programmed death ligand-1 (PD-L1) negative costimulatory molecules, soluble format sPD-1 in patients with immune thrombocytopenia (ITP), and to investigate their correlation with the secretion of cytokines. A total of 35 patients with ITP were...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Y,Pang N,Wang X,Liu Y,Wang X,Wang L,Sun M,Yasen H,Zhao F,Fan W,Guo X,Ding J

更新日期：2018-04-03 00:00:00

abstract：:Vaccination status is more often evaluated by up-to-date vaccination coverage rather than timeliness of immunization. Delaying vaccination may be dangerous during infancy. The aim of this study was to identify the importance of potentially dangerous vaccination delay (previously defined) and determinants of these dela...

journal_title：Human vaccines & immunotherapeutics

authors： Bailly AC,Gras P,Lienhardt JF,Requillart JC,Vié-le-Sage F,Martinot A,Dubos F

更新日期：2018-04-03 00:00:00

abstract：:The study of influenza virus evolution in humans has revealed a significant role of glycosylation profile alterations in the viral glycoproteins - hemagglutinin (HA) and neuraminidase (NA), in the emergence of both seasonal and pandemic strains. Viral antigenic drift can modify the number and location of glycosylation...

journal_title：Human vaccines & immunotherapeutics

authors： Cruz E,Cain J,Crossett B,Kayser V

更新日期：2018-03-04 00:00:00

abstract：:Control programs for emerging influenza are in urgent need of novel therapeutic strategies to mitigate potentially devastating threats from pathogenic strains with pandemic potential. Current vaccines and antivirals have inherent limitations in efficacy, especially with rapid evolutionary changes of influenza viruses....

journal_title：Human vaccines & immunotherapeutics

authors： Berry CM

更新日期：2018-03-04 00:00:00

abstract：:This was a randomized, placebo-controlled, Phase I/II study conducted in a Japanese cohort to assess the safety and immunogenicity of Clostridium difficile vaccine (the same formulation as that used in the ongoing global Phase III study). Healthy Japanese adults aged 40-75 years were randomized to receive either C. di...

journal_title：Human vaccines & immunotherapeutics

authors： Matsuoka O,Patel DM,Sasaki S,Oka H,Sasaki T,Pietrobon PJ,Laot T,Bouckenooghe A,Menezes J,de Bruyn G

更新日期：2018-02-01 00:00:00

abstract：:Pandemic outbreaks of influenza type A viruses have resulted in numerous fatalities around the globe. Since the conventional influenza vaccines (CIV) provide less than 20% protection for individuals with weak immune system, it has been considered that broadly cross-neutralizing antibodies may provide a better protecti...

journal_title：Human vaccines & immunotherapeutics

authors： Mendoza M,Ballesteros A,Qiu Q,Pow Sang L,Shashikumar S,Casares S,Brumeanu TD

更新日期：2018-02-01 00:00:00

abstract：:Limited safety data are available on inadvertent exposure to quadrivalent human papillomavirus vaccine (4vHPV) during pregnancy. We conducted a descriptive observational postlicensure safety surveillance study in Kaiser Permanente Southern California and Northern California to assess congenital anomaly and miscarriage...

journal_title：Human vaccines & immunotherapeutics

authors： Sy LS,Meyer KI,Klein NP,Chao C,Velicer C,Cheetham TC,Ackerson BK,Slezak JM,Takhar HS,Hansen J,Deosaransingh K,Liaw KL,Jacobsen SJ

更新日期：2018-02-01 00:00:00

abstract：:A 9-valent HPV (9vHPV) vaccine has been developed to protect against HPV type 6/11/16/18/31/33/45/52/58-related infection and disease. Previous safety analyses from 7 clinical trials conducted in 9vHPV vaccine recipients 9-26 years of age, including comparisons of 9vHPV and quadrivalent HPV (qHPV) vaccines in girls an...

journal_title：Human vaccines & immunotherapeutics

authors： Moreira ED,Giuliano AR,de Hoon J,Iversen OE,Joura EA,Restrepo J,Van Damme P,Vandermeulen C,Ellison MC,Krick A,Shields C,Heiles B,Luxembourg A

更新日期：2018-02-01 00:00:00

abstract：:Measles virus (MV) is the only human virus within the morbillivirus genus of the Paramyxoviridae. The veterinary members are canine distemper virus (CDV), peste des petits ruminants virus (PPRV), Rinderpest Virus (RPV) as well as the marine morbilliviruses phocine distemper virus (PDV), dolphin morbillivirus (DMV) and...

journal_title：Human vaccines & immunotherapeutics

authors： Cosby SL,Weir L

更新日期：2018-01-02 00:00:00

abstract：OBJECTIVES:Periodical assessments of population susceptibility to polioviruses (PV) is essential for evaluating population protection and planning appropriate vaccination strategies. The aim of the current work was to assess serological protective titers against all three polioviruses in the general population of Flore...

journal_title：Human vaccines & immunotherapeutics

authors： Giammanco GM,Bechini A,Urone N,Bonura F,Li Muli S,De Grazia S,Bellini I,Tiscione E,Boccalini S,Nastasi A

更新日期：2018-01-01 00:00:00

abstract：:Despite the long-term efficacy and immune persistence observed following HBV vaccination of infants, the need for a booster dose following infant immunization continues to be deliberated. Evidence from HBV booster dose response studies and long-term immunization program reviews are the basis for the recommendation tha...

journal_title：Human vaccines & immunotherapeutics

authors： Osiowy C

更新日期：2018-01-01 00:00:00

abstract：:Immune memory after hepatitis B vaccination among adults is still under investigation. In this study, adults who had normal and high antibody response to the primary series of hepatitis B vaccination (HepB) were followed up at 5 years after the primary immunization. A booster dose was given to those who had low hepati...

journal_title：Human vaccines & immunotherapeutics

authors： Wu W,Lv J,Liu J,Yan B,Feng Y,Xu A,Zhang L

更新日期：2018-01-01 00:00:00

abstract：:HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27Gag and HIV-1 Env and found that priming vaccination with CE DNA is...

journal_title：Human vaccines & immunotherapeutics

authors： Hu X,Lu Z,Valentin A,Rosati M,Broderick KE,Sardesai NY,Marx PA,Mullins JI,Pavlakis GN,Felber BK

更新日期：2018-01-01 00:00:00

abstract：:Pregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines. 42 pairs of mothers-infants were participated in the study. Protect...

journal_title：Human vaccines & immunotherapeutics

authors： Kostinov MP,Cherdantsev AP,Kuselman AI,Akhmatova NK,Kostinova AM,Deryabina EV,Demina EO,Kostinov AM

更新日期：2018-01-01 00:00:00

abstract：:Although catch-up campaigns (CCs) at the introduction of pneumococcal conjugate vaccines (PCVs) may accelerate their impact, supply constraints may limit their benefit if the need for additional PCV doses results in introduction delay. We studied the impact of PCV13 introduction with and without CC in Nha Trang, Vietn...

journal_title：Human vaccines & immunotherapeutics

authors： Le Polain De Waroux O,Edmunds WJ,Takahashi K,Ariyoshi K,Mulholland EK,Goldblatt D,Choi YH,Anh DD,Yoshida LM,Flasche S

更新日期：2018-01-01 00:00:00

abstract：:We aimed to determine the efficacy of the 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in children aged 18-months to <18-years with recurrent protracted bacterial bronchitis (rPBB), chronic suppurative lung disease (CSLD) or bronchiectasis. In a multi-centre, double-blind randomi...

journal_title：Human vaccines & immunotherapeutics

authors： O'Grady KF,Chang AB,Cripps A,Mulholland EK,Smith-Vaughan H,Wood N,Danchin M,Thornton R,Wilson A,Torzillo PJ,Morris PM,Richmond P,Rablin S,Arnold D,Connor A,Goyal V,Stoney T,Perrett K,Grimwood K

更新日期：2018-01-01 00:00:00

abstract：:Antipoverty vaccines are the vaccines targeting a group of approximately 20 neglected tropical diseases (NTDs), as currently defined by the World Health Organization (WHO). The "antipoverty" moniker refers to the fact that NTDs trap populations in poverty due to their chronic and deleterious effects on child intellect...

journal_title：Human vaccines & immunotherapeutics

authors： Hotez PJ

更新日期：2018-01-01 00:00:00

abstract：:Background: We performed a systematic review to evaluate factors affecting uptake of rotavirus vaccine amongst physicians, parents and health system. Methods: We identified 15 studies that met the inclusion criteria from 790 screened studies published between Jan 2005 to Jan 2016. Results: Perceived severity of rotavi...

journal_title：Human vaccines & immunotherapeutics

authors： Apte A,Roy S,Bavdekar A,Juvekar S,Hirve S

更新日期：2018-01-01 00:00:00

abstract：:In late September 2016, the Americas became the first region in the world to have eliminated endemic transmission of measles virus. Several other countries have also verified measles elimination, and countries in all six World Health Organization regions have adopted measles elimination goals. The public health strate...

journal_title：Human vaccines & immunotherapeutics

authors： Gastañaduy PA,Banerjee E,DeBolt C,Bravo-Alcántara P,Samad SA,Pastor D,Rota PA,Patel M,Crowcroft NS,Durrheim DN

更新日期：2018-01-01 00:00:00

abstract：:Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis. However, after the introduction of the whole-cell pertussis vaccine (wP), the annual incidence rates of the disease progressively declined. Despite this result, the inclusion of wP in the national immunization schedule of infants and ...

journal_title：Human vaccines & immunotherapeutics

authors： Esposito S,Principi N

更新日期：2018-01-01 00:00:00

abstract：:"Non-specific effects" of vaccines go beyond the specific protective effects against the targeted diseases. They, if real, could theoretically be beneficial, neutral or negative. This article intends to answer the following questions: Do the non-specific effects of vaccines exist? Almost certainly yes, and they can be...

journal_title：Human vaccines & immunotherapeutics

authors： Donzelli A,Schivalocchi A,Giudicatti G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Community acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide, and is a leading cause of hospitalization in previously healthy individuals without predisposing risk factors or comorbidities. In this study we determined PCV13 serotype distribution in adults aged ≥50 years with radio...

journal_title：Human vaccines & immunotherapeutics

authors： Regev-Yochay G,Chowers M,Chazan B,Gonzalez E,Gray S,Zhang Z,Pride M

更新日期：2018-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common cause of respiratory tract infections in both children and elderly people. In this study we evaluated the short- and long-term protective efficacy of a single intranasal (IN) immunization with a RSV vaccine formulation consisting of a codon-optimized fusion (F) prot...

journal_title：Human vaccines & immunotherapeutics

authors： Garg R,Latimer L,Gerdts V,Potter A,van Drunen Littel-van den Hurk S

更新日期：2017-12-02 00:00:00

abstract：:Medical scientific societies have the core mission of producing, pooling and disseminating solid and updated scientific information. We report the successful experience of the partnership of four national Medical Scientific Societies active in Italy in producing scientific advice on vaccines and vaccination. In partic...

journal_title：Human vaccines & immunotherapeutics

authors： Bonanni P,Chiamenti G,Conforti G,Maio T,Odone A,Russo R,Scotti S,Signorelli C,Villani A,Scientific Board of “Lifetime Immunization Schedule”.

更新日期：2017-11-02 00:00:00

abstract：:Purpose: Gaps remain in the public's knowledge of the human papillomavirus (HPV). We assessed racial/ethnic and gender disparities in knowledge and awareness of HPV and the HPV vaccine among US adults. METHODS:Data from the Health Information National Trends Survey 4 Cycle 3 (September - December 2013) and Cycle 4 (A...

journal_title：Human vaccines & immunotherapeutics

authors： Adjei Boakye E,Tobo BB,Rojek RP,Mohammed KA,Geneus CJ,Osazuwa-Peters N

更新日期：2017-11-02 00:00:00

abstract：:Anti-vaccination movement has existed as long as the vaccines themselves, but its mode of action and social influences evolved over time. Such attitude with no doubt has negative impact on vaccination rates and eradication of infectious diseases. In this study, we used an online survey to examine vaccination attitudes...

journal_title：Human vaccines & immunotherapeutics

authors： Zarobkiewicz MK,Zimecka A,Zuzak T,Cieślak D,Roliński J,Grywalska E

更新日期：2017-11-02 00:00:00

abstract：OBJECTIVE:To evaluate the incidence of adverse events following administration of an Inactivated poliomyelitis vaccine (IPV) manufactured by Serum Institute of India Pvt. Ltd., Pune, India. METHODS:A single 0.5 ml dose of the IPV was administered intramuscularly to children attending private clinics or out-patient dep...

journal_title：Human vaccines & immunotherapeutics

authors： Sharma H,Dhere R,Parekh S,Shewale S

更新日期：2017-11-02 00:00:00

abstract：:Human papillomavirus is considered the causative factor for cervical cancer, which accounts for approximately 5% of the global cancer burden and more than 600,000 new cases annually that are attributable to HPV infection worldwide. The first-generation prophylactic HPV vaccines, Gardasil® and Cervarix®, were licensed ...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang Z,Zhang J,Xia N,Zhao Q

更新日期：2017-10-03 00:00:00

abstract：:Influenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in China. Poor influenza vaccine effectiveness (VE) was reported in the 2014/15 season in some Northern Hemisphere countries with a predominance of H3N2 viruses belonging to the 3C.2a clade. However, th...

journal_title：Human vaccines & immunotherapeutics

authors： Ma C,Pan Y,Zhang L,Zhang Y,Wu S,Sun Y,Duan W,Zhang M,Wang Q,Yang P

更新日期：2017-10-03 00:00:00

abstract：:Tuberculosis (TB) is a significant cause of illness and death worldwide. Immunotherapy has been investigated in the treatment of TB. The purpose of this study was to perform a meta-analysis investigating the effectiveness of the M. vaccae vaccine. Medline, Cochrane, EMBASE, and Google Scholar were searched until Novem...

journal_title：Human vaccines & immunotherapeutics

authors： Huang CY,Hsieh WY

更新日期：2017-09-02 00:00:00

abstract：:The currently available drugs to treat hepatitis B virus (HBV) infection include interferons and nucleos(t)ide analogs, which can only induce disease remission and are inefficient for the functional cure of patients with chronic HBV infection (CHB). Since high titers of circulating hepatitis B surface antigen (HBsAg) ...

journal_title：Human vaccines & immunotherapeutics

authors： Gao Y,Zhang TY,Yuan Q,Xia NS

更新日期：2017-08-03 00:00:00

abstract：:Cancer vaccines are designed to stimulate the body's immune system to kill tumor cells. To improve their immunogenicity, vaccine antigens must be combined with adjuvants which are able to stimulate the innate immunity and potentiate the adaptive immune response. In the last years a new generation of adjuvants mimickin...

journal_title：Human vaccines & immunotherapeutics

authors： Circelli L,Tornesello M,Buonaguro FM,Buonaguro L

更新日期：2017-08-03 00:00:00

abstract：:Tumor cells escape from immune recognition by several mechanisms such as down-regulating of MHC class I molecules, losing of tumor antigens, etc. The purpose of cancer immunotherapy is to robust or reconstruct the capacity of the immune system to recognize and kill tumor cells by overwhelming the mechanisms by which t...

journal_title：Human vaccines & immunotherapeutics

authors： Sheikhi A,Jafarzadeh A

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:Many low- to middle-income countries have completed or are in the process of transitioning from high or intermediate to low endemicity for hepatitis A virus (HAV). Because the risk of severe hepatitis A disease increases with age at infection, decreased incidence that leaves older children and adults suscept...

journal_title：Human vaccines & immunotherapeutics

authors： Van Effelterre T,Guignard A,Marano C,Rojas R,Jacobsen KH

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:Vitamin D is an immunomodulating hormone, which has been associated with susceptibility to infectious diseases. METHODS:Serum vitamin D levels in 135 children ages 3-17 y were measured at baseline and hemagglutinin influenza antibody titers were measured pre- and 21 d post influenza vaccination with live at...

journal_title：Human vaccines & immunotherapeutics

authors： Lin CJ,Martin JM,Cole KS,Zimmerman RK,Susick M,Moehling KK,Levine MZ,Spencer S,Flannery B,Nowalk MP

更新日期：2017-07-03 00:00:00

abstract：:One combined measles-mumps-rubella (MMR) vaccine without Human Serum Albumin (HSA) is currently licensed in the USA (M-M-R II; Merck, USA) and another has been developed (Priorix™ [MMR-RIT, GSK, Belgium]). In this follow-up study, children from USA or Puerto Rico, who had received one dose of M-M-R II or MMR-RIT at 12...

journal_title：Human vaccines & immunotherapeutics

authors： Berry AA,Abu-Elyazeed R,Diaz-Perez C,Mufson MA,Harrison CJ,Leonardi M,Twiggs JD,Peltier C,Grogg S,Carbayo A,Shapiro S,Povey M,Baccarini C,Innis BL,Henry O

更新日期：2017-07-03 00:00:00

abstract：:The effective protective HIV vaccine should elicit either protective antibodies or effective T cell response, or both. To improve the efficacy of HIV-1 vaccines, HLA polymorphism and HIV-1 diversity are 2 key factors to be considered for vaccine development. In this study, we expressed a recombinant multi-epitope prot...

journal_title：Human vaccines & immunotherapeutics

authors： Yang Y,Zhu Q,Sun W,Guo J,Ning X,Li Q,Guo Y,Li J,Kou Z,Zhou Y

更新日期：2017-06-03 00:00:00

abstract：:A universal vaccine that provides long-lasting protection from both epidemic and pandemic influenza viruses remains the "holy grail" of influenza vaccine research. Though virus neutralization assays are the current benchmark of measuring vaccine effectiveness, it is clear that Fc-receptor functions can drastically imp...

journal_title：Human vaccines & immunotherapeutics

authors： Jegaskanda S,Vanderven HA,Wheatley AK,Kent SJ

更新日期：2017-06-03 00:00:00

abstract：:Higher-valent pneumococcal conjugate vaccines (PCVs) were licensed from 2009 in Europe; similar worldwide clinical effectiveness was observed for PCVs in routine use. Despite a proven medical need, PCV vaccination in Southern Europe remained suboptimal until 2015/16. We searched PubMed for manuscripts published betwee...

journal_title：Human vaccines & immunotherapeutics

authors： Moreira M,Castro O,Palmieri M,Efklidou S,Castagna S,Hoet B

更新日期：2017-06-03 00:00:00

abstract：:Japanese encephalitis (JE) is a serious public health concern in most of Asia. The disease is caused by JE virus (JEV), a flavivirus transmitted by Culex mosquitoes. Several vaccines have been developed to control JE in endemic areas as well as to protect travelers and military personnel who visit or are commissioned ...

journal_title：Human vaccines & immunotherapeutics

authors： Hegde NR,Gore MM

更新日期：2017-06-03 00:00:00